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MCH (human, mouse, rat) TFA is a potent peptide agonist of MCH-R and exhibits binding IC 50 values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. MCH (human, mouse, rat) is a highly
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Secretin (33-59), rat (TFA) is a 27-aa peptide, which acts on secretin receptor , and enhances the secretion of bicarbonate, enzymes, and K + from the pancreas.Appearance:SolidIC50& Target:Secretin receptorBiological Activity:Secretin (33-59), rat (TFA) is a
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Image Search Results
Journal: Aging (Albany NY)
Article Title: Transcranial direct current stimulation promotes angiogenesis and improves neurological function via the OXA-TF-AKT/ERK signaling pathway in traumatic brain injury
doi: 10.18632/aging.205724
Figure Lengend Snippet: tDCS promotes the expression of OXA and OX1R in TBI rats. ( A ) Representative western blotting images of Orexin-A and Orexin-A receptor 1 (OX1R) on 14 days post-TBI. Using GAPDH as an internal reference for band density normalization ( n = 3). ( B ) Quantification of western blotting for Orexin-A expression ( n = 3). ( C ) Quantification of western blotting for OX1R expression ( n = 3). ( D ) Representative immunofluorescence images of OX1R expression in brain tissue ( n = 3). ( E ) Quantification of immunofluorescence for OX1R expression ( n = 3). ( F ) Quantitative analysis of mRNA levels of OX1R expression ( n = 3). Results are expressed as means ± standard deviation, the statistical significance of differences was evaluated by One-way ANOVA, * represents the comparison between the Sham group and the TBI group, # signifies the comparison between the TBI group and the tDCS group, and & denotes the comparison between the tDCS group and the Sham-tDCS group. P < 0.05 indicates statistical significance.
Article Snippet: In order to investigate the influence of
Techniques: Expressing, Western Blot, Immunofluorescence, Standard Deviation, Comparison
Journal: Aging (Albany NY)
Article Title: Transcranial direct current stimulation promotes angiogenesis and improves neurological function via the OXA-TF-AKT/ERK signaling pathway in traumatic brain injury
doi: 10.18632/aging.205724
Figure Lengend Snippet: Orexin-A improved scratch wound healing and angiogenesis of TNF-α-injured HUVEC cells. ( A ) The image shows the effect of Orexin-A (TO1: 0.1 μM, TO2: 0.5 μM and TO3: 1 μM) on wound healing of TNF-α (10 ng/ml) injured cells. ( B ) Quantification of Orexin-A on wound closure ( n = 3). ( C ) Representative images of the study effects of TNF-α (10 ng/ml) and the three concentrations (TO1: 0.1, TO2: 0.5 and TO3: 1 μM) of Orexin-A on tube formation. ( D ) Quantification of the effects of Orexin-A on the number of capillary-like tubes in TNF-α-treated cells ( n = 3). Results are expressed as means ± standard deviation, the statistical significance of differences was evaluated by One-way ANOVA, * denotes the comparison between the Sham group and the TBI group, # represents the comparison between the TBI and the Sham-tDCS group, & signifies the comparison between the tDCS group and the Sham-tDCS group, and ¥ indicates the comparison between the tDCS group and the tDCS+SB334867 group. P < 0.05 indicates statistical significance.
Article Snippet: In order to investigate the influence of
Techniques: Standard Deviation, Comparison
Journal: Aging (Albany NY)
Article Title: Transcranial direct current stimulation promotes angiogenesis and improves neurological function via the OXA-TF-AKT/ERK signaling pathway in traumatic brain injury
doi: 10.18632/aging.205724
Figure Lengend Snippet: Orexin-A enhanced HUVEC angiogenesis and wound healing through TF-AKT/ERK pathway. ( A ) Representative images depicting the combined administration of LY3214996 (1 μM) and Orexin-A (0.5 μM) on wound healing effects. ( B ) The quantification of scratch assay results for each group is shown, measuring the closure of scratch gaps ( n = 3). ( C ) Representative images illustrating the impact of the combined administration of LY3214996 (1 μM) and Orexin-A (0.5 μM) on vascular formation. ( D ) Displays the quantification of tube formation assay results for each group, calculating the number of formed tubes ( n = 3). ( E ) Representative gross morphology of Matrigel in situ ( n = 3). ( F ) Representative H&E-stained images of matrix plug sections ( n =3). ( G ) Representative immunofluorescence images of CD31-positive cells within matrix plugs. ( H ) Quantitative analysis of the proportion of CD31-positive cells within matrix plugs ( n = 3). Results are expressed as means ± standard deviation, the statistical significance of differences was evaluated by One-way ANOVA, * denotes the comparison between the Sham group and the TBI group, # represents the comparison between the TBI and the Sham-tDCS group, & signifies the comparison between the tDCS group and the Sham-tDCS group, and ¥ indicates the comparison between the tDCS group and the tDCS+SB334867 group. P < 0.05 indicates statistical significance.
Article Snippet: In order to investigate the influence of
Techniques: Wound Healing Assay, Tube Formation Assay, In Situ, Staining, Immunofluorescence, Standard Deviation, Comparison